http://www.embomolmed.org embo EarlyView RSS Feed http://www.embomolmed.org/details/journalArticle/765327/Pathogens_under_scrutiny_in_the_south_of_France.html The first EMBO workshop on Emerging Themes in Infection Biology was held last June in the South of France. It gathered scientists working on various pathogens from viruses and bacteria to larger eukaryotic fungi and parasites. Topics included not only the crosstalk between pathogens and their hosts but also the tools researchers are using to study and image such cellular and molecular conversations. So it is said that if you know your enemies and know yourself, you can win a hundred battles... 2010-07-30T00:00:00Z http://www.embomolmed.org/details/journalArticle/765325/Gaining_the_hard_yard_preclinical_evaluation_of_lentiviralmediated_gene_therapy_.html See related article in EMBO Mol Med (Roselli et al. (2010) EMBO Mol Med 2: 315-328) 2010-07-30T00:00:00Z http://www.embomolmed.org/details/journalArticle/761607/Regulation_of_liver_regeneration_by_growth_factors_and_cytokines.html The capability of the liver to fully regenerate after injury is a unique phenomenon essential for the maintenance of its important functions in the control of metabolism and xenobiotic detoxification. The regeneration process is histologically well described, but the genes that orchestrate liver regeneration have been only partially characterized. Of particular interest are cytokines and growth factors, which control different phases of liver regeneration. Historically, their potential... 2010-07-22T00:00:00Z http://www.embomolmed.org/details/journalArticle/761613/Correction_of_thalassemia_major_by_gene_transfer_in_haematopoietic_progenitors_o.html See accompanying article: http://dx.doi.org/10.1002/emmm.201000086 2010-07-21T00:00:00Z http://www.embomolmed.org/details/journalArticle/761611/Inhibition_of_transglutaminase_2_mitigates_transcriptional_dysregulation_in_mode.html Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial biogenesis. Here we show that transglutaminase 2, which is upregulated in HD, exacerbates transcriptional dysregulation by acting as a selective corepressor of nuclear genes; transglutaminase 2 interacts directly with histone H3 in the nucleus. In a cellular model of HD,... 2010-07-21T00:00:00Z http://www.embomolmed.org/details/journalArticle/761609/Prion_protein_and_Arelated_synaptic_toxicity_impairment.html See accompanying article: http://dx.doi.org/10.1002/emmm.201000088. 2010-07-21T00:00:00Z http://www.embomolmed.org/details/journalArticle/760707/Instructions_to_Authors.html 2010-07-15T00:00:00Z http://www.embomolmed.org/details/journalArticle/760705/EMBO_Mol_Med_72010.html No Abstract. 2010-07-15T00:00:00Z http://www.embomolmed.org/details/journalArticle/760709/Oncolytic_targeting_of_renal_cell_carcinoma_via_encephalomyocarditis_virus.html Apoptosis is a fundamental host defence mechanism against invading microbes. Inactivation of NF-B attenuates encephalomyocarditis virus (EMCV) virulence by triggering rapid apoptosis of infected cells, thereby pre-emptively limiting viral replication. Recent evidence has shown that hypoxia-inducible factor (HIF) increases NF-B-mediated anti-apoptotic response in clear-cell renal cell carcinoma (CCRCC) that commonly exhibit hyperactivation of HIF due to the loss of its principal negative... 2010-07-08T00:00:00Z http://www.embomolmed.org/details/journalArticle/760713/Caseation_of_human_tuberculosis_granulomas_correlates_with_elevated_host_lipid_m.html The progression of human tuberculosis (TB) to active disease and transmission involves the development of a caseous granuloma that cavitates and releases infectious Mycobacterium tuberculosis bacilli. In the current study, we exploited genome-wide microarray analysis to determine that genes for lipid sequestration and metabolism were highly expressed in caseous TB granulomas. Immunohistological analysis of these granulomas confirmed the disproportionate abundance of the proteins involved in... 2010-07-01T00:00:00Z http://www.embomolmed.org/details/journalArticle/760711/Angiotensin_II_revisited_new_roles_in_inflammation_immunology_and_aging.html That the renin-angiotensin system (RAS) is involved in regulation of blood pressure, vasoconstriction, sodium intake and potassium excretion is well established. Studies in the last few years have however documented new roles for this molecule as a pro-inflammatory molecule and more recently as a possible pro-fibrotic agent that contributes to progressive deterioration of organ function in disease. Binding of Ang II to its receptors (in particular AT1) mediates intracellular free radical... 2010-07-01T00:00:00Z http://www.embomolmed.org/details/journalArticle/760715/Cancer_and_neurodegeneration_meet.html No Abstract. 2010-06-25T00:00:00Z http://www.embomolmed.org/details/journalArticle/743953/Oxidative_stress_promotes_myofibroblast_differentiation_and_tumour_spreading.html JunD regulates genes involved in antioxidant defence. We took advantage of the chronic oxidative stress resulting from junD deletion to examine the role of reactive oxygen species (ROS) in tumour development. In a model of mammary carcinogenesis, junD inactivation increased tumour incidence and revealed an associated reactive stroma. junD-inactivation in the stroma was sufficient to shorten tumour-free survival rate and enhance metastatic spread. ROS promoted conversion of fibroblasts into... 2010-06-09T00:00:00Z http://www.embomolmed.org/details/journalArticle/743951/High_mobility_group_box1_recognition_The_beginning_of_a_RAGEless_era.html High mobility group box 1 (HMGB1) is a molecular alarm signal that triggers an immune response when released. It was assumed that the receptor for advanced glycation end-products (RAGE) would mediate the signal to the immune system. Recently pattern recognition receptors that are triggered by molecules of bacterial origin (the Toll-like receptor (TLR) family) were shown to also respond to HMGB1. Now two papers establish the TLR4-HMGB1 axis as proinflammatory, eventually leading to disparate... 2010-06-09T00:00:00Z http://www.embomolmed.org/details/journalArticle/743959/HIV1_replication_activates_CD4_T_cells_with_specificities_for_persistent_herpes_.html Hyperactivation of CD4+ T cells is a hallmark of untreated HIV-1 infection. The antigenic specificities of activated CD4+ T cells and the underlying mechanisms leading to their activation remain thus far elusive. We report here that during HIV rebound the dynamics of HIV-specific CD4+ T cells is highly correlated with the dynamics of CD4+ T cells specific for persistent antigens derived from various members of the herpes virus family, whereas CD4 responses towards non-persistent antigens were... 2010-06-08T00:00:00Z