http://www.embomolmed.org embo current issue RSS Feed http://www.embomolmed.org/details/journalArticle/760705/EMBO_Mol_Med_72010.html No Abstract. 2010-07-15T00:00:00Z http://www.embomolmed.org/details/journalArticle/760707/Instructions_to_Authors.html 2010-07-15T00:00:00Z http://www.embomolmed.org/details/journalArticle/743951/High_mobility_group_box1_recognition_The_beginning_of_a_RAGEless_era.html High mobility group box 1 (HMGB1) is a molecular alarm signal that triggers an immune response when released. It was assumed that the receptor for advanced glycation end-products (RAGE) would mediate the signal to the immune system. Recently pattern recognition receptors that are triggered by molecules of bacterial origin (the Toll-like receptor (TLR) family) were shown to also respond to HMGB1. Now two papers establish the TLR4-HMGB1 axis as proinflammatory, eventually leading to disparate... 2010-06-09T00:00:00Z http://www.embomolmed.org/details/journalArticle/743955/Inositolrequiring_1Xboxbinding_protein_1_is_a_regulatory_hub_that_links_endoplas.html Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses. 2010-06-08T00:00:00Z http://www.embomolmed.org/details/journalArticle/692385/Mutations_for_the_people.html See related article by Dias-Santagata D et al DOI 10.1002/emmm.201000070 2010-05-11T00:00:00Z http://www.embomolmed.org/details/journalArticle/692379/Rapid_targeted_mutational_analysis_of_human_tumours_a_clinical_platform_to_guide.html See accompanying article: 10.1002/emmm.201000071 2010-04-29T00:00:00Z http://www.embomolmed.org/details/journalArticle/678683/Rewarding_excellence_in_biomedical_research.html No Abstract. 2010-04-01T00:00:00Z http://www.embomolmed.org/details/journalArticle/678685/Pluripotent_stem_cells_private_obsession_and_public_expectation.html No Abstract. 2010-04-01T00:00:00Z http://www.embomolmed.org/details/journalArticle/575373/A_systems_biology_approach_to_understanding_atherosclerosis.html Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many different cellular systems to perturbations. Such a network analysis strategy using pathway information and... 2010-03-03T00:00:00Z http://www.embomolmed.org/details/journalArticle/575371/The_promise_and_the_challenge_of_modelling_human_disease_in_a_dish.html No Abstract. 2010-02-17T00:00:00Z http://www.embomolmed.org/details/journalArticle/559369/EMBO_Mol_Med_22010.html No Abstract. 2010-02-04T00:00:00Z http://www.embomolmed.org/details/journalArticle/559149/Instructions_to_Authors.html 2010-02-04T00:00:00Z http://www.embomolmed.org/details/journalArticle/559371/Instructions_to_Authors.html 2010-02-04T00:00:00Z http://www.embomolmed.org/details/journalArticle/528257/EMBO_Mol_Med_12010.html No Abstract. 2009-12-30T00:00:00Z http://www.embomolmed.org/details/journalArticle/528259/On_the_bumpy_road_towards_personalized_medicine.html No Abstract. 2009-12-30T00:00:00Z