http://www.brjpharmacol.org EarlyView RSS Feed http://www.brjpharmacol.org/details/journalArticle/748129/Biological_actions_of_green_tea_catechins_on_cardiac_troponin_C.html Background and purpose: Catechins, biologically active polyphenols in green tea, are known to have a protective effect against cardiovascular diseases. In this study, we investigated direct actions of green tea catechins on cardiac muscle function to explore their uses as potential drugs for cardiac muscle disease.Experimental approach: The effects of catechins were systematically investigated on the force-pCa relationship in skinned cardiac muscle fibers to determine their direct effects on... 2010-06-29T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/748127/The_antiaggregating_effect_of_BAY_412272_a_stimulator_of_soluble_guanylyl_cyclas.html Background and purpose: The purpose of the present study was to determine whether a stimulator of soluble guanylyl cyclase, BAY 41-2272, inhibits platelet aggregation and to clarify its interaction with nitric oxide (NO).Experimental approach: Blood was collected from anaesthetized WKY rats. The aggregation of washed platelets was measured and the production of cAMP and cGMP was determined.Key results: In ADP-induced platelet aggregation, the anti-aggregating effects of BAY 41-2272,... 2010-06-29T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747407/Block_and_allosteric_modulation_of_GABAergic_currents_by_oenanthotoxin_in_rat_cu.html Background and purpose: Oenanthotoxin (OETX), a polyacetylenic alcohol from plants of the genus Oenanthe, has recently been identified as potent inhibitor of GABA-evoked currents. However, the effects of OETX on the inhibitory postsynaptic currents (IPSCs), as well as the pharmacological mechanism(s) underlying its effects on GABAA receptors, remain unknown. The purpose of this study was to elucidate the mechanism underlying the inhibition of GABAergic currents by OETX.Experimental approach: ... 2010-06-25T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747057/Suppression_of_antibodymediated_arthritis_in_mice_by_Fab_fragments_of_the_mediat.html Background and purpose: Fab fragments (Fabs) of antibodies maintain the ability to bind specific antigens but lack the binding site for complement as well as the site for binding to receptors on effector cells, such as macrophages that play an important role in inflammation. In the present study, we investigated whether Fabs specific for ovalbumin (OVA) were specifically able to suppress anti-OVA antibody-mediated arthritis (AOA-MA) in mice.Experimental approach: AOA-MA was induced by i.v.... 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747055/Principles_of_Antidote_Pharmacology_An_Update_on_Prophylaxis_PostExposure_Treatm.html The use of biological agents has generally been confined to military-led conflicts. However, there has been an increase in non-state based terrorism, including the use of asymmetric warfare, such as biological agents in the past few decades. Thus, it is becoming increasingly important to consider strategies for preventing and preparing for attacks by insurgents, such as the development of pre- and post-exposure medical countermeasures. There are a wide range of prophylactics and treatments... 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747053/Strategies_to_improve_efficacy_and_safety_of_a_novel_class_of_antiviral_hyperact.html Background and purpose: Anti-viral hyper-activation limiting therapeutic agents (AV-HALT) are a novel experimental drug class designed to both decrease viral replication and down-regulate excessive immune system activation for the treatment of chronic infections, including HIV/AIDS. VS411, a first-in-class AV-HALT, is a single dosage form combining didanosine (ddI, 400 mg), an antiviral, and hydroxyurea (HU, 600 mg), a cytostatic agent, designed to provide a slow release of ddI to reduce its... 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747051/Mitochondrial_monoamine_oxidase_Amediated_hydrogen_peroxide_generation_enhances_.html Background and purpose: We evaluated the role(s) of monoamine oxidase (MAO)-mediated H2O2 generation on 5-HT-induced tension development of isolated basilar artery of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats.Experimental approach: Basilar artery (endothelium-denuded) was isolated for tension measurement and Western blots. Enzymically dissociated single myocytes from basilar arteries were used for patch-clamp electrophysiological and confocal microscopic... 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747087/An_operational_model_of_pharmacological_agonism_the_effect_of_EA_curve_shape_on_.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747085/The_pharmacology_of_cimetidine_a_new_histamine_H2receptor_antagonist.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747083/Commentary_on_Receptors_mediating_some_actions_of_histamine_by_ASF_Ash_and_HO_Sc.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747081/An_analysis_of_the_depressor_responses_to_histamine_in_the_cat_and_dog_involveme.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747079/Commentary_on_An_analysis_of_the_depressor_responses_to_histamine_in_the_cat_and.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747077/COMPARISON_OF_SOME_PROPERTIES_OF_PRONETHALOL_AND_PROPRANOLOL.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747075/Commentary_on_Comparison_of_some_properties_of_pronethalol_and_propranolol_by_JW.html 2010-06-24T00:00:00Z http://www.brjpharmacol.org/details/journalArticle/747073/A_Life_in_New_Drug_Research.html 2010-06-24T00:00:00Z